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Synthesis and characterization of new N-phenylmaleimide thioglycosides
Authors:Bader A. Salameh  Kayed A. Abu-Safieh  Sanaa R. A. Al-Kaabenah  Raed A. Al-Qawasmeh
Affiliation:1. Department of Chemistry, The Hashemite University, P.O. Box 150459, Zarqa, 13115, Jordan
2. Department of Chemistry, The University of Jordan, Amman, 11942, Jordan
Abstract:Thioglycosides derivatives of N-phenylmaleimide have been prepared by the reaction of derivatives of 1-thio-d-glucopyranose, d-galactopyranose, d-lactose, and d-maltose with 3,4-dichloro-N-phenylmaleimide. The reaction of 3,4-dichloro-N-phenyl maleimide with sugar thiols (protected or unprotected) took place by displacement of both chlorine atoms by sulfide nucleophile giving the corresponding bis-thioglycoside products.
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