Synthesis of sterically hindered phenol-containing phosphorylated isatin derivatives |
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| Authors: | Yu N Oludina S V Bukharov A R Burilov R G Tagasheva V V Syakaev R Z Musin E F Akhmetova G N Nugumanova |
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| Institution: | 1. Kazan National Research Technological University, 68 ul. K. Marksa, 420015, Kazan, Russian Federation
2. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, 8 ul. Akad. Arbuzova, 420088, Kazan, Russian Federation
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| Abstract: | Addition of isatin to the exocyclic double bond of dimethyl (3,5-di-tert-butyl-4-oxocyclohexa-2,5-dienylidene)methylphosphonate gave dimethyl (3,5-di-tert-butyl-4-hydroxyphenyl)(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methylphosphonate. Its subsequent functionalization in reactions with thiosemicarbazide and 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionohydrazide yielded isatin derivatives containing several pharmacophoric fragments. |
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