| Glyoxylic acid as catalyst： A simple selective synthesis of 1,2-disubstituted benzimidazoles in aqueous media |
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| 引用本文： | Shivaji S. Pawar,Deepak V. Dekhane,Murlidhar S. Shingare,Shivaji N. Thore. Glyoxylic acid as catalyst： A simple selective synthesis of 1,2-disubstituted benzimidazoles in aqueous media[J]. 中国化学快报, 2008, 19(9): 1055-1058. DOI: 10.1016/j.cclet.2008.06.028 |
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| 作者姓名： | Shivaji S. Pawar Deepak V. Dekhane Murlidhar S. Shingare Shivaji N. Thore |
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| 作者单位： | a Department of Chemistry, Vinyakrao Patil Mahavidyaia Vaijapur, Aurangabad 423701(M.S.), India;b Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004(M.S.), India |
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| 基金项目： | The authors are thankful to Head, Department of Chemistry, Vinayakrao Patil Mahavidyala Vaijapur 423701 （M.S.）, India, for partial support of this work. |
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| 摘 要： | Glyoxylic acid （5 mol%） performs as a novel highly water-soluble catalyst for the synthesis of 2-aryl-l-arylmethyl-lH- benzimidazoles from a wide range of substituted o-phenylenediamines and various substituted aldehydes in good to excellent isolated yields （85-95%） using water as solvent at ambient temperature. The remarkable advantages offered by this method are easily and inexpensive available catalyst, simple procedure, mild conditions, much faster （20--40 rain） reactions and excellent yields of products.
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| 关 键 词： | 催化剂 苯并咪唑 水媒体 医学化学 |
Glyoxylic acid as catalyst: A simple selective synthesis of 1,2-disubstituted benzimidazoles in aqueous media |
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| Shivaji S. Pawar,Deepak V. Dekhane,Murlidhar S. Shingare,Shivaji N. Thore. Glyoxylic acid as catalyst: A simple selective synthesis of 1,2-disubstituted benzimidazoles in aqueous media[J]. Chinese Chemical Letters, 2008, 19(9): 1055-1058. DOI: 10.1016/j.cclet.2008.06.028 |
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| Authors: | Shivaji S. Pawar Deepak V. Dekhane Murlidhar S. Shingare Shivaji N. Thore |
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| Affiliation: | a Department of Chemistry, Vinyakrao Patil Mahavidyaia Vaijapur, Aurangabad 423701(M.S.), India;b Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004(M.S.), India |
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| Abstract: | Glyoxylic acid (5 tool%) performs as a novel highly water-soluble catalyst for the synthesis of 2-aryl-l-arylmethyl-lH-benzimidazoles from a wide range of substituted o-phenylenediamines and various substituted aldehydes in good to excellent isolated yields (85-95%) using water as solvent at ambient temperature. The remarkable advantages offered by this method are easily and inexpensive available catalyst, simple procedure, mild conditions, much faster (20-40 min) reactions and excellent yields of products. |
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| Keywords: | Glyoxylic acid Benzimidazoles Aqueous media 2-Aryl-l-arylmethyl-lH-benzimidazoles o-Phenylenediamines and aldehydes |
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