Hybrid gadolinium oxide nanoparticles: multimodal contrast agents for in vivo imaging |
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Authors: | Bridot Jean-Luc Faure Anne-Charlotte Laurent Sophie Rivière Charlotte Billotey Claire Hiba Bassem Janier Marc Josserand Véronique Coll Jean-Luc Elst Luce Vander Muller Robert Roux Stéphane Perriat Pascal Tillement Olivier |
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Affiliation: | Laboratoire de Physico-Chimie des Matériaux Luminescents, UMR 5620 CNRS-Université Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France. |
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Abstract: | Luminescent hybrid nanoparticles with a paramagnetic Gd2O3 core were applied as contrast agents for both in vivo fluorescence and magnetic resonance imaging. These hybrid particles were obtained by encapsulating Gd2O3 cores within a polysiloxane shell which carries organic fluorophores and carboxylated PEG covalently tethered to the inorganic network. Longitudinal proton relaxivities of these particles are higher than the positive contrast agents like Gd-DOTA which are commonly used for clinical magnetic resonance imaging. Moreover these particles can be followed up by fluorescence imaging. This study revealed that these particles suited for dual modality imaging freely circulate in the blood vessels without undesirable accumulation in lungs and liver. |
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