Microwave assisted synthesis of indole-annulated dihydropyrano[3,4-c]chromene derivatives via hetero-Diels-Alder reaction |
| |
| Authors: | Mukund Jha Stephanie GuyTing-Yi Chou |
| |
| Affiliation: | Department of Biology and Chemistry, Nipissing University, North Bay, ON, Canada P1B 8L7 |
| |
| Abstract: | An efficient two-step synthesis of indole-annulated dihydropyrano[3,4-c]chromene derivatives is achieved via Knoevenagel condensation of O-propargylated salicylaldehyde derivatives with indolin-2-ones followed by a microwave-assisted intramolecular-hetero-Diels-Alder reaction of the resulting (Z)-3-(2-(prop-2-ynyloxy)benzylidene)indolin-2-ones in the presence of 20 mol % CuI in acetonitrile. |
| |
| Keywords: | Indole Indolin-2-one Dihydropyran Chromene Benzopyran Hetero-Diels-Alder Knoevenagel reaction |
| 本文献已被 ScienceDirect 等数据库收录！ |
