Total synthesis of khafrefungin using highly stereoselective vinylogous Mukaiyama aldol reaction |
| |
| Authors: | Shirokawa Shin-ichi Shinoyama Mariko Ooi Isao Hosokawa Seijiro Nakazaki Atsuo Kobayashi Susumu |
| |
| Institution: | Faculty of Pharmaceutical Sciences, Tokyo University of Science (RIKADAI), 2641 Yamazaki, Noda-shi, Chiba 278-8510, Japan. |
| |
| Abstract: | structure: see text] A convergent total synthesis of khafrefungin was accomplished on the basis of (1) the highly stereoselective TiCl4-mediated vinylogous Mukaiyama aldol reaction using vinylketene silyl N,O-acetal and (2) syn-selective aldol reaction of enal 5a and ethyl ketone 6 followed by anti-dehydration under Mitsunobu conditions. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
