Cobalt phthalocyanine as a biomimetic catalyst in the amperometric quantification of dipyrone using FIA |
| |
Authors: | Boni Ana Carolina Wong Ademar Dutra Rosa Amália Fireman Sotomayor Maria Del Pilar Taboada |
| |
Affiliation: | a Department of Analytical Chemistry, Institute of Chemistry, State University of São Paulo (UNESP), 14801-970 Araraquara, SP, Brazil b Laboratory of Diagnostic Research (LAPED), University of Pernambuco, 50100-130 Recife, PE, Brazil |
| |
Abstract: | A biomimetic sensor for the determination of dipyrone was prepared by modifying carbon paste with cobalt phthalocyanine (CoPc), and used as an amperometric detector in a flow injection analysis (FIA) system. The results of cyclic voltammetry experiments suggested that CoPc behaved as a biomimetic catalyst in the electrocatalytic oxidation of dipyrone, which involved the transfer of one electron. The optimized FIA procedure employed a flow rate of 1.5 mL min−1, a 75 μL sample loop, a 0.1 mol L−1 phosphate buffer carrier solution at pH 7.0 and amperometric detection at a potential of 0.3 V vs. Ag/AgCl. Under these conditions, the proposed method showed a linear response for dipyrone concentrations in the range 5.0 × 10−6-6.3 × 10−3 mol L−1. Selectivity and interference studies were carried out in order to validate the system for use with pharmaceutical and environmental samples. In addition to being environmentally friendly, the proposed method is a sensitive and selective analytical tool for the determination of dipyrone. |
| |
Keywords: | Biomimetic catalyst Cobalt phthalocyanine Dipyrone Flow injection system |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|