Plasmalemmal Vesicle Associated Protein-1 (PV-1) is a marker of blood-brain barrier disruption in rodent models |
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| Authors: | Eveline H Shue Eleanor B Carson-Walter Yang Liu Bethany N Winans Zarina S Ali Jun Chen Kevin A Walter |
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| Institution: | (1) Department of Neurosurgery, University of Pittsburgh, 15213 Pittsburgh, PA, USA;(2) Department of Neurosurgery, University of Rochester, 14642 Rochester, NY, USA;(3) Department of Neurology, University of Pittsburgh, 15213 Pittsburgh, PA, USA |
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| Abstract: | Background
Plasmalemmal vesicle associated protein-1 (PV-1) is selectively expressed in human brain microvascular endothelial cells derived from clinical specimens of primary and secondary
malignant brain tumors, cerebral ischemia, and other central nervous system (CNS) diseases associated with blood-brain barrier
breakdown. In this study, we characterize the murine CNS expression pattern of PV-1 to determine whether localized PV-1 induction is conserved across species and disease state. |
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