Chiral recognition and resolution of the enantiomers of supramolecular triangular hosts: synthesis, circular dichroism, NMR, and X-ray molecular structure of [Li subset(R,R,R)-[CpRh(5-chloro-2,3-dioxopyridine)]3][Delta-Trisphat |
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Authors: | Mimassi Lamia Guyard-Duhayon Carine Rager Marie Noelle Amouri Hani |
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Institution: | Laboratoire de Chimie Inorganique et Matériaux Moléculaires, UMR CNRS 7071, Université Pierre et Marie Curie Paris VI, 4 place Jussieu, case 42, 75252 Paris Cedex 05, France. |
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Abstract: | The racemic triangular supramolecular host CpRh(5-chloro-2,3-dioxopyridine)](3) (1) was prepared in high yield. Treatment with LiCl followed by addition of silver salt AgOTf gave the triflate salt species Li subsetCpRh(5-chloro-2,3-dioxopyridine)](3)]OTf] (2). Subsequent anion metathesis using the optically pure chiral shift reagent Cinchonidinium]Delta-Trisphat] produced a pair of diastereomers Li subset(R,R,R)-CpRh(5-chloro-2,3-dioxopyridine)](3)]Delta-Trisphat] (3a) and Li subset(S,S,S)-CpRh(5-chloro-2,3-dioxopyridine)](3)]Delta-Trisphat] (3b). The resolution of these diastereomers was achieved by fractional crystallization, and their stereochemistry relationship was established by circular dichroism studies. The X-ray molecular structure of 3a is reported and shows as an outstanding feature a chiral recognition between the Delta-Trisphat anion and a single enantiomer cation Li subset(R,R,R)-CpRh(5-chloro-2,3-dioxopyridine)](3)](+) manifested through a pi-pi interaction. (1)H NMR and circular dichroism studies in solution support the solid-state behavior. |
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