| Enantioselective synthesis of β-amino esters bearing a quinazoline moiety via a Mannich-type reaction catalyzed by a cinchona alkaloid derivative |
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| 作者姓名： | HE Ming PAN ZhaoXi BAI Song LI Pei ZHANG YuPing JIN LinHong HU DeYu YANG Song SONG BaoAn |
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| 作者单位： | State Key Laboratory Breeding Base of Green Pesticides and Agricultural Bioengineering;Key Laboratory of Green Pesticides and Agricultural Bioengineering,Ministry of Education;Guizhou University |
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| 基金项目： | the National Key Program for Basic Research(2010CB 126105);the Key Technologies R&D Program (2011BAE06B056);the National Natural Science Foundation of China (21132003 &20962005) for the financial support |
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| 摘 要： | The cinchona alkaloids catalyzed the direct asymmetric Mannich reactions of 1,3-dicarbonyl compounds with acyl imines to produce novel β-amino ester derivatives containing a quinazoline moiety.The adducts were isolated with high enantiomeric excess(up to 99%).
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| 关 键 词： | Cinchona alkaloid-based thiourea Mannich reaction β-amino esters enantioselective synthesis |
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