Diversity-oriented synthesis of bicyclic ring systems via a conjugate addition/aldol/RCM process

Diversity-oriented synthesis (DOS) has been widely applied in the generation of a large collection of highly functionalized molecules with diverse chemical skeletons. Herein, we report the diversity-oriented synthesis of a series of structurally diverse bicyclic substrates via an efficient tandem conjugate addition/aldol process followed by ring-closing metathesis (RCM). This approach allows us to efficiently prepare a number of structurally complex molecules for the further chemical biology studies.