A nature-inspired concise synthesis of (+)-ent-chromazonarol |
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Authors: | JieHui Huang XiaoGuang Lei |
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Affiliation: | 1. College of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, China 2. National Institute of Biological Sciences (NIBS), Beijing, 102206, China
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Abstract: | A large number of sesquiterpene quinone/hydroquinone natural products including (+)-ent-chromazonarol have been isolated and received great attention from the synthetic community. Herein, we report a nature-inspired concise synthesis of (+)-ent-chromazonarol in 4 steps from a readily available starting material. The synthesis relied on a Lewis acid mediated cyclization which correctly installed two vicinal stereocenters in one step. This highly efficient synthetic route allows us to further prepare natural product congeners for further biological studies. |
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