9-(2-Aryloxyethyl) Derivatives of Adenine - a New Class of Non-nucleosidic Antiviral Agents |
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| Authors: | V. I. Petrov A. A. Ozerov M. S. Novikov C. Pannecouque J. Balzarini E. De Clercq |
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| Affiliation: | (1) Scientific Research Institute for Pharmacology, Volgograd State Medical University, Volgograd, 400131, Russia;(2) Rega Institute for Medical Research, Catholic University, Leuvain, Belgium |
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| Abstract: | New 9-(aryloxyalkyl) derivatives of adenine have been prepared by alkylation of adenine with tosylates, bromides, and  -chloro ethers containing terminal aromatic fragments in anhydrous DMF in the presence of potassium carbonate. The compounds of the 9-(2-phenoxyethyl)adenine series appear to be highly reactive against cytomegaloviruses of mankind in vitro, while derivatives of 9-(2-benzyloxyethyl)adenine demonstrate anti-HIV-1 activity. Compounds with shorter or longer chains, and also compounds which do not have aromatic fragments at the ends of the chains, do not possess antiviral activity. |
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| Keywords: | adenine N(9)-alkylation antiviral activity |
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