Synthesis of Trinorditerpenoid Derivatives and Evaluation of Antimicrobial and Cytotoxic Activity期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis of Trinorditerpenoid Derivatives and Evaluation of Antimicrobial and Cytotoxic Activity

Authors:	R. Alonso H. Gomis A. Taddei C. Sajo

Affiliation:	(1) Centro de Quimica, Instituto Venezolano de Investigaciones Cientificas (IVIC), Caracas, 1020-A, Venezuela;(2) Departamento de Biologia Celular, Universidad Simon Bolivar, (USB), Apartado 89000, Caracas, 1080-A, Venezuela

Abstract:	The synthesis of optically active trinorditerpenes was carried out, and their antimicrobial and antitumor activity was tested. The synthetic derivative 12-hydroxypodocarpa-8,11,13-triene (7) showed GI₅₀ at 6.6 µM against breast cancer MDA-MB-435 (LC₅₀ = 50.9 µM and log10 GI₅₀ = −5.18). The 12-acetyloxypodocarpa-8,11,13-triene (8) showed GI₅₀ at 12.1 µM against leukemia RPMI-8226 (LC₅₀ = 76.1 µM and log₁₀GI₅₀ = −4.92).__________Published in Khimiya Prirodnykh Soedinenii, No. 3, pp. 255–259, May–June, 2005.

Keywords:	trinorditerpenoid derivatives antimicrobial and cytotoxic activity
本文献已被 SpringerLink 等数据库收录！