Solute effects on the helix-coil transition |
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| Authors: | O Farago P Pincus |
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| Institution: | (1) Materials Research Laboratory, University of California, Santa Barbara, CA 93106, USA, US |
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| Abstract: | We discuss the effects of the solvent composition on the helix-coil transition of a polypeptide chain. We use a simple model
to demonstrate that improving the hydrogen-bonding ability of the solvent can make the transition less cooperative, without
affecting the transition temperature. This effect is very different from other solvent effects which primarily influence the
melting transition rather than the cooperativity.
Received 10 December 2001 and Received in final form 22 March 2002 |
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| Keywords: | PACS 87 15 -v Biomolecules: structure and physical properties – 05 70 Fh Phase transitions: general studies – 61 41 +e Polymers elastomers and plastics |
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