| 医用高分子水凝胶的设计与合成 |
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| 引用本文： | 王轶,张黎明. 医用高分子水凝胶的设计与合成[J]. 功能高分子学报, 2004, 17(2): 330-336 |
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| 作者姓名： | 王轶 张黎明 |
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| 作者单位： | 中山大学化学与化学工程学院,聚合物复合材料与功能材料教育部重点实验室,广东,广州,510275;中山大学化学与化学工程学院,聚合物复合材料与功能材料教育部重点实验室,广东,广州,510275 |
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| 基金项目： | 国家自然科学基金(20273086)，教育部留学回国人员基金，广东省自然科学基金(021769，039184) |
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| 摘 要： | 作为一类重要的医用功能材料，高分子水凝胶可望在药物控释、软骨支架构建、活性细胞封装等方面获得广泛应用。综述了基于化学交联和物理交联的有关水凝胶的设计与合成方法，重点介绍了通过自由基共聚反应、结构互补基团间化学反应形成的化学交联水凝胶以及通过荷电相反离子问相互作用、两亲性嵌段或接枝共聚物疏水缔合、结晶与氢键相互作用形成的物理交联水凝胶。
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| 关 键 词： | 高分子水凝胶 化学交联 物理交联 医用材料 |
| 文章编号： | 1008-9357(2004)02-0330-07 |
| 修稿时间： | 2003-11-20 |
Design and Synthesis of Polymeric Hydrogels for Biomedical Applications |
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| WANG Yi,ZHANG L-wing. Design and Synthesis of Polymeric Hydrogels for Biomedical Applications[J]. Journal of Functional Polymers, 2004, 17(2): 330-336 |
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| Authors: | WANG Yi ZHANG L-wing |
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| Abstract: | As a class of important biomedical functional materials, polymeric hydrogels have a great potential applications in drug delivery system, cartilage scaffold and the encapsulation of living cells. In this article, their design and preparation methods based on chemical and physical cross]inking were reviewed, in which special emphasis was given to chemically cross]inked hydrogels formed by radical polymerization and chemical reaction of complementary groups as well as to physically crosslinking hydrogels formed by.ionic interactions, hydropbobic association of ampbophilic block and graft copolymers in aqueous solutions, crystallization and hydrogen bonds. |
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| Keywords: | polymeric hydrogel chemical crosslinking physical crosslinking biomedical materials |
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