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Determination of the enantiomeric composition of chiral carboxylic acids using chiral derivatization and HPLC |
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| Authors: | L. Ladányi I. Sztruhár P. Slégel G. Vereczekey-Donáth |
| Affiliation: | (1) EGIS Pharmaceuticals, P.O. Box 100, H-1475 Budapest, Hungary |
| Abstract: | Summary The enantiomers of chiral carboxylic acids were separated as their diastereomeric amides with (1R,2R)-(−)-1-(4-nitrophenyl)-2-amino-1,3-propanediol (“levobase”) and with “dextrobase” (the enantiomer of levobase) by high-performance liquid chromatography using a conventional C-18 column and various solvent systems containing acetonitrile, methanol, water, and phosphoric acid. |
| Keywords: | Column liquid chromatography Chiral carboxylic acid Enentiomeric resolution Chiral derivatization |
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