| 配位微环境对Hg(Ⅱ)-血清白蛋白结构的影响 |
| |
| 引用本文： | 李舒婷,查丹明,梁宏,周永洽,申泮文.配位微环境对Hg(Ⅱ)-血清白蛋白结构的影响[J].光谱学与光谱分析,1999,19(5):700-703. |
| |
| 作者姓名： | 李舒婷 查丹明 梁宏 周永洽 申泮文 |
| |
| 作者单位： | 1. 广西师范大学生物无机化学研究所化学系,541004,桂林
2. 南开大学化学系,300071,天津 |
| |
| 基金项目： | 国家自然科学基金，广西十百千人才基金 |
| |
| 摘 要： | 详细研究了等点附近Ｈｇ－ＨＳＡ或ＢＳＡ体系的紫外光谱。与生理ｐＨ时的谱图相比较，Ｈｇ－ＢＳＡ的２５０ｎｍ附近谱带消失或变弱，而２９０ｎｍ谱带及Ｈｇ－ＨＳＡ的光谱基本不变。这一差异进一步支持了Ｈｇ离子在ＨＳＡ或ＢＳＡ中最可能的结合位置在７对相邻的二硫桥处，金属中心有四面体型ＭＳ４结构的推断。
|
| 关 键 词： | Hg(Ⅱ)-HSA Hg(Ⅱ)-BSA 紫外光谱 配位微环境 金属中心结构 |
Effect of the Coordinate Micro-environment on the Structure of Hg(Ⅱ)-Serum Albumin |
| |
| Shuting LI,Danming ZHA,Hong LIANG,Yongqia ZHOU,Panwen SHEN.Effect of the Coordinate Micro-environment on the Structure of Hg(Ⅱ)-Serum Albumin[J].Spectroscopy and Spectral Analysis,1999,19(5):700-703. |
| |
| Authors: | Shuting LI Danming ZHA Hong LIANG Yongqia ZHOU Panwen SHEN |
| |
| Institution: | Guangxi Normal University, 541004 Guilin. |
| |
| Abstract: | Detailed studies on the UV spectra of Hg (II)-HSA or Hg (II)-BSA complexes nearby isoionic point were carried out in this paper. Compared with the spectra at physiological pH, the band nearby 250 nm of Hg (II)-BSA generally disappeared or widened and weakened,but the band at 290 nm of Hg (II)-BSA and Hg (II)-HSA remained nearly unchanged. These results support that these binding sites of Hg (II)-serum albumin may be located at seven pairs of adjacent disulfide bridges and there might be the structure of HgS4 tetrahedral configuration. For the first time, this paper put forward the solid figure of HgS4 tetrahedral configuration, and further discussed the results using the discrepancy of the coordinate micro-environment. |
| |
| Keywords: | |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
