Molecular recognition: Supramolecular, polymeric and biomimetic coatings for chemical sensors and chromatographic columns |
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Authors: | T Wessa and Wolfgang G?pel |
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Institution: | (1) Schering AG, Müllerstra?e 170–178, D-13342 Berlin, Germany, DE;(2) Institute of Physical and Theoretical Chemistry and “Center of Interface Analysis and Sensors”, University of Tübingen, D-72076 Tübingen, Germany e-mail: thomas.wessa@schering.de, DE |
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Abstract: | Complete control of the selective and reversible interaction of molecules from the gas or liquid phase at complementary recognition
sites is of increasing interest for both basic science and practical applications. This recognition may occur at the surface
or in the bulk of optimized chemically sensitive coatings. It is either monitored discontinuously by chromatography or continuously
by a suitable sensor. The latter contains the optimized coating and converts the chemical information about concentrations
of certain molecules by means of a certain transducer into an electronic signal. Generally speaking, these transducers form
the essential part of ‘chemical sensors’; they monitor the molecular interactions at the chemically sensitive layer by changes
in resistivity, impedance, mass, capacitance, work function, heat, electrochemical potential, optical thickness, or optical
absorption in a certain spectral range. Three selected case studies of such molecular recognition devices which utilize supramolecular,
polymeric, and biomimetic coatings are presented. Examples are given for both gas and liquid sensing devices. For simplification,
because of its general applicability and its easy absolute calibration, particular emphasis is put on signal transduction
via quartz crystal oscillators. The measurement principle is based on frequency changes which are directly correlated with
mass changes and thus provide a particularly suitable signal transduction. The examples presented here concern systematic
variations in the design of supramolecular cages, of selective interaction sites in polymeric matrices, and of covalently
attached biomimetic recognition sites to monitor antibodies or enzyme interactions.
Received: 11 August 1997 / Revised: 3 March 1998 / Accepted: 3 March 1998 |
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