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Efficient fabrication of substrates for surface-assisted laser desorption/ionization mass spectrometry using laser ablation in liquids |
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| Authors: | Takeshi Tsuji,Takeshi MizukiMasato Yasutomo,Masaharu TsujiHideya Kawasaki,Tetsu YonezawaFumitaka Mafuné |
| Affiliation: | a Institute of Advanced Materials Chemistry and Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, 6-1 Kasuga-Koen, Kasuga, Fukuoka 816-8580, Japan b Department of Applied Chemistry, Faculty of Engineering, Kansai University, 3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan c Division of Materials Science and Engineering, Faculty of Engineering, Hokkaido University, Kita 13, Nishi 8, Kita-ku, Sapporo, Hokkaido 060-8628, Japan d Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro, Tokyo 153-8902, Japan |
| Abstract: | Substrates for the surface-assisted laser desorption ionization (SALDI) technique were prepared using electrophoresis of gold nanoparticles produced by laser ablation in liquids. Throughout the preparation, no supplemental reagent was added for the stabilization and deposition of nanoparticles. Nanoparticles were deposited more uniformly using the electrophoresis technique than using dropping of the solution. Results demonstrated that the higher uniformity of the deposition of nanoparticles improved the reproducibility of SALDI measurements. Furthermore, the thickness of the deposited nanoparticles influences the SALDI efficiency. |
| Keywords: | Laser ablation Nanoparticles Colloids Electrophoresis Surface-assisted laser desorption/ionization SALDI Mass spectrometry |
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