Mechanical and corrosion resistance of hydrophilic sphene/titania composite coatings on titanium and deposition and release of cefazolin sodium/chitosan films |
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Authors: | Su ChengDaqing Wei Yu Zhou |
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Institution: | a Institute for Advanced Ceramics, Department of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, PR China b School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150001, PR China |
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Abstract: | The mechanical and corrosion resistance of hydrophilic sphene/titania composite coatings on titanium formed by a hybid technique of microarc oxidation (MAO) and heat-treatment were investigated. The results indicated that the heat-treatment could improve the hardness, elastic modulus, elastic recovery and corrosion resistance of the MAO coatings, and reinforce the interface bonding between MAO coatings and titanium. A cefazolin sodium/chitosan drug film was prepared on the coating surfaces. The drug load procedures such as the addition of chitosan obviously increased the sustained-release ability of drug films. In addition, the increase of cefazolin sodium concentration could increase the accumulative release concentration of cefazolin sodium. The sustaining-release ability of drug films deposited on the MAO and heat-treated MAO coatings is similar. In the interior of drug film, the physical and chemical bonding reactions such as Coulombic interactions, van der Waals force and H-bonding etc. could be produced, through the chemical group interactions such as -OH and -NH2 groups of chitosan with -C O of cefazolin sodium. |
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Keywords: | Titanium Sphene Cefazolin sodium Chitosan Microarc oxidation Heat-treatment |
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