|
|||||
|
|
Robust routes for the synthesis of N-acylated-l-homoserine lactone (AHL) quorum sensing molecules with high levels of enantiomeric purity |
|
| Authors: | James T HodgkinsonWarren RJD Galloway Mariangela CasoliHarriet Keane Xianbin SuGeorge PC Salmond Martin WelchDavid R Spring |
| Institution: | a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom b Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, United Kingdom |
| Abstract: | The ready availability of native quorum sensing molecules and related structural analogues is of significant biological interest in the development of methods to manipulate bacterial quorum sensing systems in a useful fashion. In this Letter we report robust routes for the synthesis of a range of N-acylated-l-homoserine lactone (AHL) quorum sensing molecules. Crucially, we have analysed the enantiopurity of the final AHLs and in all cases, excellent levels were observed. |
| Keywords: | Quorum sensing l-homoserine lactones (AHLs)" target="_blank">N-acylated-l-homoserine lactones (AHLs) Synthesis Enantiomeric purity Pseudomonas aeruginosa |
| 本文献已被 ScienceDirect 等数据库收录！ | |