|
|||||
|
|
Synthesis of Resveratrol Analogs/Stilbene Derivatives and Their Nitric Oxide Inhibitory and Radical Scavenging Activities |
|
| Authors: | WANG Jue ZHANG Cunlong WANG Tiejie LI Xiaofan |
| Affiliation: | 1. Shenzhen Institute for Drug Control, Shenzhen 518057, P. R. China; 2. Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences, Shenzhen University, Shenzhen 518060, P. R. China; 3. Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P. R. China |
| Abstract: | Sixteen resveratrol analogs(stilbene derivatives) including resveratrol were synthesized, in which hydroxystilbenes, naturally occurring polyphenols, showed protective effects against reactive oxygen and nitrogen species(ROS/RNS) and hexahydroxystilbene(16) displayed the strongest activities against NO and 1,1-diphenyl- 2-picrylhydrazyl(DPPH) with IC50 values of 7.8 and 5.7 μmol/L, respectively. |
| Keywords: | Resveratrol Stilbene Nitric oxide Radical |
| 本文献已被 维普 万方数据 等数据库收录！ | |
| 点击此处可从《高等学校化学研究》浏览原始摘要信息 | |
| 点击此处可从《高等学校化学研究》下载全文 | |