Protic ionic liquid [TMG][Ac] as an efficient,homogeneous and recyclable catalyst for Boc protection of amines |
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| Authors: | Jafar Akbari Akbar Heydari Leila Ma’mani Seyed Hassan Hosseini |
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| Institution: | Chemistry Department, Tarbiat Modares University, Aleahmad street, P.O. Box 14155-4838, Tehran, Iran |
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| Abstract: | An efficient and practical protocol for the chemoselective N-Boc protection of various structurally different aryl, aliphatic and heterocyclic amines was carried out with (Boc)2O using protic 1, 1, 3, 3-tetra-methylguanidinium acetate (10 mol%) as recyclable catalyst under solvent free condition at ambient temperature. No competitive side reactions (isocyanate, urea and N, N-di-Boc) were observed. α-Amino alcohols afforded the N-Boc-derivative without oxazolidinone formation. |
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