Enantioselective hydrosilylation of prochiral ketones catalyzed by chiral BINAP-copper(I) complexes |
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| Authors: | Jean-Thomas Issenhuth Samuel Dagorne Stéphane Bellemin-Laponnaz |
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| Affiliation: | CNRS, université de Strasbourg, institut de chimie, 1, rue Blaise-Pascal, 67000 Strasbourg, France |
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| Abstract: | The CuCl/NaOt-Bu/BINAP system was found to efficiently catalyze the hydrosilylation of aryl alkyl ketones with excellent enantioselectivities by using phenyl methyl silane as a stoichiometric hydride source. High enantiomeric excesses (up to 97%) and excellent yields (up to 99%) were obtained. |
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