| 咪唑类氮氧自由基的ESR波谱的酸度相关性-pH自旋探针应用研究之一 |
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| 引用本文： | 刘利,丛建波.咪唑类氮氧自由基的ESR波谱的酸度相关性-pH自旋探针应用研究之一[J].波谱学杂志,1997,14(2):173-178. |
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| 作者姓名： | 刘利 丛建波 |
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| 作者单位： | 1. 中国科学技术大学研究生院化学部, 北京 100039;2. 军事医学科学院放射医学研究所, 北京 100850 |
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| 基金项目： | This work was supported by the National Natural Science Foundation of China |
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| 摘 要： | 根据咪唑类氮氧自由基的结构特性合成了一系列的pH自旅探针,其ESR波谱参数均在一定范围内与介质的酸性呈明显的相关性.可望为较精确地测量化学胶束、细胞等微观体系的pH值开辟一个新的途径.本文研究了灵敏变化的pH范围与取代基的关系,得到了5种自旅探针的ESR参数-pH曲线、pKa值以及Hanmmett相关图,分析了如何通过改变取代基合成出不同pH变化范围并适用于不同生物和化学体系的pH自旅探针,最终达到付诸应用的目的.
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| 关 键 词： | 咪唑类氮氧自由基 pH自旋探针 ESR谱 |
| 收稿时间： | 1996-10-03 |
THE INFLUENCE OF MEDIUM ACIDITY ON THE ESR SPECTRA OF IMIDAZOLINE NITROXIDE RADICALS: The Application Research of pH Spin Probes Ⅰ |
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| Liu Li,Zhao Hongtao,Ma Yao,Zhang Jianzhong,Cong Jianbo,Sun Cunpu.THE INFLUENCE OF MEDIUM ACIDITY ON THE ESR SPECTRA OF IMIDAZOLINE NITROXIDE RADICALS: The Application Research of pH Spin Probes Ⅰ[J].Chinese Journal of Magnetic Resonance,1997,14(2):173-178. |
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| Authors: | Liu Li Zhao Hongtao Ma Yao Zhang Jianzhong Cong Jianbo Sun Cunpu |
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| Institution: | 1. Graduate School, Academia Sinica, Beijing 100039;2. Institute of Radiation Medicine, Beijing 100850 |
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| Abstract: | Imidazoline nitroxide radicals were synthesized and studied as "pH probes".The influence of pH on the ESR spectra of the radicals were discussed and their pKa values were measured. The substituent R on the phenyl ring has an effect on the proton exchangerate of the N3 atom which is related to the pKa value of the nitroxide radical. |
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| Keywords: | Imidazoline nitroxide radical pH spin probe ESR |
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