Acylation of 2H,6H-2,6-dimethyl-4-amino-1,3,5-dithiazine and tautomerism of the reaction products

The acylation of 2H,6H-2,6-dimethyl-4-amino-1,3,5-dithiazine with the chlorides and anhydrides of saturated carboxylic and sulfonic acids leads to N-monoacyl derivatives of dithiazine in 85–96% yields. It was established by IR and UV spectroscopy that 2H,6H-2,6-dimethyl-4-acylamino-1,3,5-dithiazines with donor substituents exist primarily in the amino form and that the equilibrium is shifted to favor the imino form for compounds with acceptor substituents to a greater degree in solutions than in the crystalline state.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 622–626, May, 1982.