A rapid and convergent synthesis of the integrastatin core |
| |
| Authors: | Tadross Pamela M Bugga Pradeep Stoltz Brian M |
| |
| Institution: | The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, California Institute of Technology, Division of Chemistry and Chemical Engineering, Mail Code 101-20, Pasadena, CA 91125, USA. |
| |
| Abstract: | The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapid manner. Our strategy relies upon a palladium(II)-catalyzed oxidative cyclization to form the central 3.3.1]-dioxabicycle of the natural product core. Overall, the core has been completed in only 4 linear steps from known compounds. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
