| A New Cytotoxic Compound from Penicillium auratiogriseum, Symbiotic or Epiphytic Fungus of Sponge Mycale plumose |
| |
| 作者姓名： | Zhi Hong XIN Wei Ming ZHU* Qian Qun GU Yu Chun FANG Lin DUAN Cheng Bin CUI Key Laboratory of Marine Drugs of Chinese Ministry of Education Marine Drugs and Food Institute Ocean University of China Qingdao |
| |
| 作者单位： | Zhi Hong XIN，Wei Ming ZHU*，Qian Qun GU，Yu Chun FANG，Lin DUAN，Cheng Bin CUI Key Laboratory of Marine Drugs of Chinese Ministry of Education，Marine Drugs and Food Institute，Ocean University of China，Qingdao 266003 |
| |
| 基金项目： | 国家高技术研究发展计划(863计划)，国家自然科学基金 |
| |
| 摘 要： | To investigate the bioactive metabolites from marine microbes,the fungus Penicillium auratiogriseum was isolated from the sponge Mycale plumose collected in Qingdao,China.The ethyl acetate extract of the fermentation broth of P.auratiogriseum showed significant cytoxicity in the mouse cdc2mutant cell line(tsFT210).Thus5L of liquid medium was inoculated with the purely isolated fungus and incubated at25?C for9days.The cultured broth was extracted three times with the equivalent volume of et…
|
A New Cytotoxic Compound from Penicillium auratiogriseum, Symbiotic or Epiphytic Fungus of Sponge Mycale plumose |
| |
| Zhi Hong XIN,Wei Ming ZHU*,Qian Qun GU,Yu Chun FANG,Lin DUAN,Cheng Bin CUI Key Laboratory of Marine Drugs of Chinese Ministry of Education,Marine Drugs and Food Institute,Ocean University of China,Qingdao .A New Cytotoxic Compound from Penicillium auratiogriseum, Symbiotic or Epiphytic Fungus of Sponge Mycale plumose[J].Chinese Chemical Letters,2005,16(9). |
| |
| Authors: | Zhi Hong XIN Wei Ming ZHU Qian Qun GU Yu Chun FANG Lin DUAN Cheng Bin CUI |
| |
| Abstract: | A new compound, (S)-2, 4-dihydroxy-1-butyl (4-hydroxy) benzoate (1), and a known compound, fructigenines A (2), were isolated from fungus Penicillium auratiogriseum derived from sponge Mycale plumose, by bioassay-guided fractionation. Their structures were established by spectroscopic and chemical methods. Both compounds showed cytotoxic activity against tsFT210 cells. |
| |
| Keywords: | Penicillium auratiogriseum Mycale plumose aromatic ester alkaloid anti-tumor activity |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
