Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal-Knorr pyrrole formation and gas concentration measurement by inline flow titration |
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| Authors: | Cranwell Philippa B O'Brien Matthew Browne Duncan L Koos Peter Polyzos Anastasios Peña-López Miguel Ley Steven V |
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| Institution: | Whiffen Laboratory, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. |
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| Abstract: | Using a simple and accessible Teflon AF-2400 based tube-in-tube reactor, a series of pyrroles were synthesised in flow using the Paal-Knorr reaction of 1,4-diketones with gaseous ammonia. An inline flow titration technique allowed measurement of the ammonia concentration and its relationship to residence time and temperature. |
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