| 视黄酸合成酶基因Raldh2敲除鼠肢体发育起始的挽救 |
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| 引用本文： | 高元奇,苏循瑞,赵显玲.视黄酸合成酶基因Raldh2敲除鼠肢体发育起始的挽救[J].分子科学学报,2007,23(2):96-98. |
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| 作者姓名： | 高元奇 苏循瑞 赵显玲 |
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| 作者单位： | 1. 东北师范大学生命科学学院,吉林,长春,130024;吉林大学医学部基础医学院,吉林,长春,130021
2. 东北师范大学生命科学学院,吉林,长春,130024 |
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| 基金项目： | 国家自然科学基金资助项目(30470903) |
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| 摘 要： | 视黄酸合成酶基因Raldh2敲除鼠胚胎心脏膨大,没有肢体发育的起始.肌细胞增强子基因Mef2C敲除鼠胚胎心脏较小,但肢体的发育起始正常.Raldh2/Mef2C双基因敲除鼠与Raldh2敲除鼠形态相似.Tbx5在Raldh2/Mef2C基因敲除鼠第9天的胚胎表达表明,双基因敲除鼠胚胎没有肢体的发育.这一结果表明Mef2C敲除鼠没有挽救Raldh2敲除鼠肢体发育的起始.
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| 关 键 词： | 视黄酸合成酶基因 肌细胞增强子基因 肢体发育 挽救 |
| 文章编号： | 24359292 |
| 修稿时间： | 12 3 2006 12:00AM |
The rescue of limb bud initiation in Raldh2 mutant |
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| GAO Yuan-qi,SU Xun-rui,ZHAO Xian-ling.The rescue of limb bud initiation in Raldh2 mutant[J].Journal of Molecular Science,2007,23(2):96-98. |
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| Authors: | GAO Yuan-qi SU Xun-rui ZHAO Xian-ling |
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| Institution: | 1. School of life Sienees,Northeast Normal University,Changchun 130024,China; 2. Basic School of Medical Sciences,Jilin University,Changchun 130021,China |
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| Abstract: | Raldh2 mutant embryo had a dilated heart and did not form limb bud.Mef2C mutant embryo had a small heart and the normal initiation of limb bud.Raldh2/Mef2C double mutant was similar to Raldh2 mutant in morphology.Tbx5 expression in the limb bud field of day 9 embryo showed that no limb bud was initiated in Raldh2/Mef2C double mutant.So Mef2C mutant did not rescue the initiation of limb bud of Raldh2 mutant. |
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| Keywords: | retinadehyde dehydrogenase myocyte enhancer factor-2 limb bud development rescue |
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