Pesticide residue analysis of a dietary ingredient by gas chromatography/selected-ion monitoring mass spectrometry using neutral alumina solid-phase extraction cleanup |
| |
Authors: | Jeong Mijeong Lee Zahn Michael Trinh Thao Brooke Fay A Ma Wenwen |
| |
Institution: | Unigen Inc., Quality Control/Quality Assurance Department, 2660 Willamette Dr, NE, Lacey, WA 98516, USA. |
| |
Abstract: | A sample cleanup procedure has been developed to remove coextractives that interfere with pesticide residue analysis of a dietary ingredient (Product B), an extract consisting of Scutellaria baicalensis and Acacia catechu. Samples were extracted using 1% acetic acid in acetonitrile, followed by solid-phase extraction and analysis by capillary gas chromatography with mass spectrometry in the selective-ion monitoring mode. Neutral alumina (alumina N) was found to be the most effective sorbent to remove coextractives from Product B; other materials that were tested but failed to remove interference were graphitized carbon black/primary-secondary amine (PSA), octadecylsilane (C18), Florisil, Oasis MCX, and strong anion exchange-PSA. The method was specifically developed for Product B, which was spiked with 41 organochlorine and organophosphorus pesticides, and resulted in the recovery of 80 to 120% at U.S. Pharmacopeia limits (0.06 to 4 microg/g) for the majority of the pesticides. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|