| Synthesis of Thiourea Derivatives on Soluble Polymeric Support |
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| 作者姓名： | YANG，Gui－Chun CHEN，Zu－Xing |
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| 作者单位： | FacultyofChemistryandMaterialsScience,HubeiUniversity,Wuhan,Hubei430062,China |
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| 基金项目： | theEducationDepartmentofHubeiProvinceChina (No.2 0 0 1A0 10 17) |
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| 摘 要： | A modified poly(ethylene glycol) (PEG) has been developed as the soluble polymeric supports for liquid phase synthesis of novel thiourea derivatives.In each step of the sequence,the PEG-bound products were precipitated in cold Et2O and the unreacted materials and by-products were removed by simple filtration.The progress of reaction,purity of the isolation and the structure of the PEG-bound products were easily monitored by TLC,IR and ^1H NMR spectra.Representative thiourea derivatives were obtained in moderate yields with excellent purity from this modified PEG-bound product by the cleavage with 50% TFA/H2O.
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| 关 键 词： | 合成 硫脲 衍生物 可溶性聚合载体 |
Synthesis of Thiourea Derivatives on Soluble Polymeric Support |
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| YANG,Gui Chun CHEN,Zu Xing ZHANG,Zhao JunFaculty of Chemistry and Material Science,Hubei University,Wuhan,Hubei ,China.Synthesis of Thiourea Derivatives on Soluble Polymeric Support[J].Chinese Journal of Chemistry,2002,20(2):178-182. |
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| Authors: | YANG Gui Chun CHEN Zu Xing ZHANG Zhao JunFaculty of Chemistry and Material Science Hubei University Wuhan Hubei China |
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| Institution: | YANG,Gui Chun CHEN,Zu Xing ZHANG,Zhao JunFaculty of Chemistry and Material Science,Hubei University,Wuhan,Hubei 430062,China |
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| Abstract: | A modified poly(ethylene glycol) (PEG) has been developed as the soluble polymeric supports for liquid phase synthesis of novel thiourea derivatives. In each step of the sequence, the PEG bound products were precipitated in cold Et 2O and the unreacted materials and by products were removed by simple filtration. The progress of reaction, purity of the isolation and the structure of the PEG bound products were easily monitored by TLC, IR and 1H NMR spectra. Representative thiourea derivatives were obtained in moderate yields with excellent purity from this modified PEG bound product by the cleavage with 50% TFA/H 2O. |
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| Keywords: | poly(ethylene glycol) (PEG) soluble polymeric supports synthesis thiourea derivatives |
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