Quantitative determination of the average molecular weights of dextrans by diffusion ordered NMR spectroscopy |
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Authors: | N. E. Kuz’mina S. V. Moiseev V. I. Krylov V. A. Yashkir V. A. Merkulov |
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Affiliation: | 1. Research Center for the Examination of Medical Products, Ministry of Health of the Russian Federation, Petrovskii bul’v. 8, Moscow, 127051, Russia
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Abstract: | Diffusion ordered NMR (DOSY) was applied to the determination of the average molecular weights of polymers based on the dependence of the measured self-diffusion coefficient D on the corresponding weights of a number of polymers of the same type. As a rule, a calibration function is plotted by varying DOSY experimental parameters for each particular test sample; however, this approach is inapplicable to the development of a standard procedure for the quantitative assessment of the molecular weights of dextrans. In this article, an optimization method is considered to ensure high resolution in terms of the values of D for dextrans without varying experimental conditions; this method makes it possible to evaluate the average molecular weights of dextrans with a high accuracy over a wide range of their values. |
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