Electrophoretic and gas-chromatographic analysis of an Afobazol pharmaceutical preparation

Procedures for determining 5-ethoxy-2-[2-(morpholino)ethylthio]benzimidazole dihydrochloride, an active component of the Afobazol medicinal preparation, and its potential impurities, 5-ethoxybenzimidazol-2-thione and N-(2-chloroethyl)morpholine hydrochloride by capillary zone electrophoresis in the range 2.0 × 10^?5 to 2.0 × 10^?3 M and ligand-exchange capillary electrophoresis in the range 1.0 × 10^?5 to 5.0 × 10^?3 M are developed. The optimum conditions for the separation and determination of these analytes using a quartz capillary tube are found. The reliability of the results obtained by capillary electrophoresis was confirmed by gas chromatography with a mass-selective detector.