Heterocyclic analogs of 5,12-naphthacenequinone. 2. Synthesis of 4,11-dihydroxynaphtho[2,3-f]indazole-5,10-dione and its n-methyl derivatives |
| |
| Authors: | A E Shchekotikhin Yu N Luzikov O S Anisimova V N Buyanov M N Preobrazhenskaya |
| |
| Institution: | (1) G. F. Gauze Institute of New Antibiotics, Russian Academy of Medical Science, Moscow, 119021, Russia;(2) Center for Drug Chemistry, All-Russian Chemical and Pharmaceutical Research Institute, Moscow, 119815;(3) Russian D. I. Mendeleev University of Chemical Technology, Moscow, 125190 |
| |
| Abstract: | On methylating 4,11-dimethoxynaphtho2,3-f]indazole-5,10-dione with methyl iodide in the presence of base a mixture is formed
of its 1-and 2-methyl derivatives. Demethylation of the methoxy groups of the starting material and of the products of its
alkylation leads to the formation of 4,11-dihydroxynaphtho2,3-f]indazole-5,10-dione (pyrazoloquinizarine) and its 1-and 2-methyl
derivatives.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 691–696, May, 2006. |
| |
| Keywords: | 4 11-dihydroxynaphtho[2 3-f]indazole-5 10-dione pyrazoloquinizarine demethylation Stokes shift fluorescence |
| 本文献已被 SpringerLink 等数据库收录！ |
|
