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| 双缩水甘油醚活化法制备免疫吸附剂及其对乙型肝炎表面抗原的吸附 | |
| 引用本文： | 李湛勇,史林启,何炳林,梁树人. 双缩水甘油醚活化法制备免疫吸附剂及其对乙型肝炎表面抗原的吸附[J]. 离子交换与吸附, 2001, 17(3): 236-241 |
| 作者姓名： | 李湛勇 史林启 何炳林 梁树人 |
| 作者单位： | 1. 南开大学高分子化学研究所；南开大学化学系 2. 南开大学高分子化学研究所, 3. 天津市传染病院, |
| 基金项目： | 国家自然科学基金(59503005) |
| 摘 要： | 采用1，4－二羟基正丁烷双缩水甘油醚活化交联壳聚糖树脂，偶联抗－乙型肝炎表面抗原单克隆抗体，制备树脂／抗体免疫吸附剂，对含乙型肝炎表面抗原的患者阳性血清的吸附试验结果表明，吸附率可达44％，能使阳性血清转为阴性。 |
| 关 键 词： | 免疫地剂 1 4－二羟基正丁烷双缩水甘油醚 交联壳聚糖树脂 乙型肝炎 表面抗 治疗 血液净化 |
| 文章编号： | 1001-5493(2001)03-0236-06 |
| 修稿时间： | 2000-12-19 |
THE PREPARATION OFIMMUNOADSORBENT BY ACTIVATION OF 1,4-BUTANEDIOL DIGLYCIDYL ETHER AND THE ADSORPTION FORHEPATITIS B SURFACE ANTIGEN |
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| LI Zhanyong, SHI Linqi HE Binglin LIANG Shuren State Key Laboratory of Functional Polymer Materials for Adsorption and Separa tion. THE PREPARATION OFIMMUNOADSORBENT BY ACTIVATION OF 1,4-BUTANEDIOL DIGLYCIDYL ETHER AND THE ADSORPTION FORHEPATITIS B SURFACE ANTIGEN[J]. Ion Exchange and Adsorption, 2001, 17(3): 236-241 | |
| Authors: | LI Zhanyong SHI Linqi HE Binglin LIANG Shuren State Key Laboratory of Functional Polymer Materials for Adsorption Separa tion |
| Affiliation: | LI Zhanyong1,2 SHI Linqi1 HE Binglin1 LIANG Shuren3 1 State Key Laboratory of Functional Polymer Materials for Adsorption and Separa tion,Institute of Polymer Chemistry,Nankai University,Tianjin 300071 2 Department of Chemistry Nankai University,Ti |
| Abstract: | The crosslinked chitosan resins were activated by 1,4-butanediol digly cidyl ether. The effect factors of activation were studied in detail and the rea ction conditions were optimized. Then the anti-HBsAg monoclonal antibody were co upled to the activated carrier to obtain the immunoadsorbent. The adsorption pro perties of the immunoadsorbent were studied in serum containing HBsAg and the ad sorption efficiency reached 44%. |
| Keywords: | Immunoadsorbent 1 4-Butanediol Diglycidyl Ether Crosslinked chitosa n resins Hepatitis B Surface antigen |
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