Synthesis of 1-morpholino-1-(phenylethynyl)cycloalkanes from enamines and phenylacetylene in the presence of Cu(I) halides |
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| Authors: | L Yu Vkhin V N Komissarov Zh I Orlova |
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| Institution: | (1) Institute of Physical and Organic Chemistry, Rostov State University, 194/3 prosp. Stachki, 344771 Rostov-on-Don, Russian Federation |
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| Abstract: | 1-Morpholino-1-(phenylethynyl)cyclopentane and 1-morpholino-1-(phenylethynyl)cyclohexane were obtained by reactions of enamines, derivatives of cyclic ketones, with phenylacetylene in the presence of CuI. A scheme for catalysis by Cu(I) compounds with the intermediate formation of copper phenylacetylide and iminium salts was suggested.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 169–170, January, 1994. |
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| Keywords: | 1-amino-1-(phenylethynyl)cycloalkanes enamines phenylacetylene copper(I) halides copper acetylides Mannich reaction iminium salts |
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