Singlet Oxygen Generation by Metallotexaphyrins |
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| Authors: | Leonard I. Grossweiner Mehmet D. Bilgin Peter Berdusis Tarak D. Mody |
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| Affiliation: | Wenske Laser Center, Ravenswood Hospital Medical Center, Chicago, IL, USA;Pharmacyclics, Inc., Sunnyvale, CA, USA |
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| Abstract: | Abstract. Metallotexaphyrins have clinical applications as photo-sensitizers of photodynamic therapy (PDT). The singlet oxygen quantum yield (φ>Δ) was determined for a series of metallotexaphyrin derivatives (Lu [III], Y [III], Cd [II], In [III] and Gd [in]) under conditions where the agents are believed to exist in monomeric form. The results show φΔ of metallotexaphyrins vary with the medium and the metal cation. Measurements on the Lu (III) texaphyrin led to φΔ= 0.38 in unbuffered 5% Tween 20 and φΔ= 0.58 in pH 7.4 phosphate buffer plus 1% Triton X-100 (±10%). The in vitro photodynamic efficiency calculated from φΔ is compared to in vivo PDT efficacy in an animal tumor model. |
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