分子印迹固相萃取技术在天然产物有效成分分离分析中的应用进展

天然产物体系复杂,尤其是一些活性成分含量较低,采用一般的方法对其进行分离富集难度较大。分子印迹聚合物具有良好的亲和性和专一的选择性,将分子印迹固相萃取技术应用于天然药物资源样品前处理过程,能够选择性地分离富集复杂基质中的目标成分。本文对近几年分子印迹固相萃取技术在天然产物有效成分分离分析中的应用进行了总结,分析物包括黄酮类、多元酚类、生物碱类、有机酸类、苯丙素类、萜类以及其他一些类型的生物活性成分。

Application of molecularly imprinted solid phase extraction in the separation and determination of active constituents from natural compounds

The active constituents of natural medicine resources are complicated and in low content, which are difficult to be extracted and separated by general methods. Molecularly imprinted polymers are functional porous materials with molecular-specific recognition sites to a particular target molecule. The molecularly imprinted solid phase extraction has been used as a sample preparation technique for the separation of active constituents from natural medicine resources. The target molecules in a mixture of chemical species can be recognized selectively. In this review, the applications of the molecularly imprinted solid phase extraction for the determination and separation of active constituents (e.g. flavonoids, polyphenols, alkaloids, organic acids, phenylpropanoids, terpenoids, etc.) from natural compounds in recent years are summarized.