| 三肽N-o-Ns-Gly-N-Me-D-Phe-L-Pro-OMe的合成 |
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| 引用本文： | 李美玲,许艳杰,姜丽琴,陈立功. 三肽N-o-Ns-Gly-N-Me-D-Phe-L-Pro-OMe的合成[J]. 化学通报, 2006, 69(3): 179-183 |
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| 作者姓名： | 李美玲 许艳杰 姜丽琴 陈立功 |
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| 作者单位： | 天津大学,药物科学与技术学院,天津,300072;天津大学,化工学院,天津,300072 |
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| 摘 要： | 以L-脯氨酸、D-苯丙氨酸和甘氨酸为原料,经酯化、Boc保护、N-甲基化、偶合、酯化、邻硝基苯磺酰基保护、水解、酰化、脱Boc保护、偶合等十步反应,合成了三肽N-o-Ns-Gly-N-Me-D-Phe-L-Pro-OMe,总收率为22·3%(以L-脯氨酸计)。
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| 关 键 词： | Tasiamide L-脯氨酸 D-苯丙氨酸 甘氨酸 |
| 收稿时间： | 2005-07-13 |
| 修稿时间： | 2005-07-132005-11-08 |
Synthesis of Tripeptide N- o -Ns- Gly- N-Me-D-Phe-L-Pro- OMe |
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| Li Meiling,Xu Yanjie,Jiang Liqin,Chen Ligong. Synthesis of Tripeptide N- o -Ns- Gly- N-Me-D-Phe-L-Pro- OMe[J]. Chemistry, 2006, 69(3): 179-183 |
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| Authors: | Li Meiling Xu Yanjie Jiang Liqin Chen Ligong |
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| Abstract: | N-o-Ns-Gly-N-Me-D-Phe-L-Pro-OMe, a tripeptide, was synthesized from L-proline, D-phenylalanine and glycine in overall yield 22.3% (based on L-Proline) through ten steps, including esterification, Boc protection, N-methylation, condensation, esterification, o-Ns protection, hydrolysis, acylation, deprotection, condensation,etc. |
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| Keywords: | Tasiamide L-Proline D-Phenylalanine Glycine |
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