| 新型含环状α-羟基膦酸酯的N1-(四氢呋喃-2-基)-5-氟尿嘧啶衍生物的合成 |
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| 引用本文： | 石德清,魏佳,谭效松. 新型含环状α-羟基膦酸酯的N1-(四氢呋喃-2-基)-5-氟尿嘧啶衍生物的合成[J]. 有机化学, 2005, 25(12): 1602-1605 |
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| 作者姓名： | 石德清 魏佳 谭效松 |
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| 作者单位： | 华中师范大学化学学院,教育部农药与化学生物学重点实验室,武汉,430079 |
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| 基金项目： | 湖北省武汉市青年科技晨光计划，重庆市应用基础研究基金 |
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| 摘 要： | 通过N1-(2-呋喃烷基)-N3-羟乙基-5-氟尿嘧啶的Moffatt氧化, 再与亚磷酸酯的加成反应合成得到8个新型含环状α-羟基膦酸酯的N1-(四氢呋喃-2-基)-5-氟尿嘧啶衍生物, 采用IR, 1H NMR, 31P NMR, MS和元素分析对其结构进行了表征.
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| 关 键 词： | 5-氟尿嘧啶 α-羟基膦酸酯 抗肿瘤药物 |
| 收稿时间： | 2005-03-15 |
| 修稿时间： | 2005-06-20 |
Synthesis of Novel 1-Furanidin-2''''-yl-5-fluorouracil Derivatives of Cyclic α-Hydroxyphosphonates |
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| SHI,De-Qing,WEI,Jia,TAN,Xiao-Song. Synthesis of Novel 1-Furanidin-2''''-yl-5-fluorouracil Derivatives of Cyclic α-Hydroxyphosphonates[J]. Chinese Journal of Organic Chemistry, 2005, 25(12): 1602-1605 |
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| Authors: | SHI De-Qing WEI Jia TAN Xiao-Song |
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| Affiliation: | Key Laboratory of Pesticide and Chemical Biology of Ministry of Education of China, College of Chemistry, Central China Normal University, Wuhan 430079 |
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| Abstract: | ight novel 5-fluorouracil derivatives containing the unit of α-hydroxyphosphonates were synthesized via the addition reactions of cyclic phosphates to 1-furanidin-2'-yl-3-formylmethyl-5-fluorouracil. The structures of the products were confirmed by IR, 1H NMR, 31P NMR, MS spectra and elemental analyses. |
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| Keywords: | 1-furanidin-2'-yl-5-fluorouracil cyclic α-hydroxyphosphonates antitumor drug |
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