An efficient and environmentally friendly DABCO catalyzed Henry reaction of isatins |
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| Authors: | HM Meshram Palakuri RameshA Sanjeeva Kumar A Swetha |
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| Institution: | Organic Chemistry Division - I, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | An efficient and general method has been described for the synthesis of 3-hydroxy-3-(nitromethyl)indolin-2-one by the reaction of isatins with nitromethane/nitroethane in the presence of DABCO. The reaction is catalytic, very rapid, yields are very high and avoids the use of solvents for reaction. The protocol is applicable for substituted isatins as well as substituted nitroalkanes. |
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