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Multi-Component Carbohydrate Coupling using Solution and Polymer Support Technology |
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| Authors: | Shino?Manabe |
| Institution: | 1.The Institute of Physical and Chemical Research (RIKEN),Wako, Saitama,Japan;2.Graduate School of Agriculture and Life Science,University of Tokyo,Yayoi, Bunkyo-ku, Tokyo,Japan |
| Abstract: | The concept of the multi-component coupling in one-pot was applied to a polymer support carbohydrate synthesis to enhance the total efficiency of the oligosaccharide synthesis. Polymer bound disaccharides and trisaccharides were synthesized in a one-pot operation by the combination of imidates and thioglycosides. The by-products and reagents were simply washed off, thereby facilitating the purification of the products. Cleavage of the saccharides from the polymer support was carried out by catalytic hydrogenation. |
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