A rapid synthesis of hexofuranose-like iminosugars using ring-closing metathesis |
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| Authors: | Cren Sylvaine Wilson Claire Thomas Neil R |
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| Institution: | School of Chemistry, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom. |
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| Abstract: | Two new 1-N-iminosugars have been prepared as hexofuranose analogues in an efficient manner by an RCM-based route. Both 3,4-disubstituted pyrrolidines display moderate inhibitory activity against Mycobacterium smegmatis galactan biosynthesis. structure: see text] |
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