Regiospecific synthesis of novel spiro-pyrimidobarbiturates with promising antibacterial activities |
| |
| Authors: | Bahgat R M Hussein Amr H Moustafa |
| |
| Institution: | Department of Chemistry, Faculty of Science, Sohag University, Sohag, Egypt |
| |
| Abstract: | In this work, a novel series of 9-amino-7-aryl-11-imino-2,4,8,10-tetraazaspiro5.5]undeca-7,9-diene-1,3,5-triones 3a-l was synthesized via the treatment of cyanoguanidine 1 with respective arylidene barbituric acids 2a-l in dry pyridine. The products were evaluated for in vitro antibacterial activity against Bacillus cereus (+G), Staphylococcus aureus (+G), Pseudomonas aeruginosa (−G) and Escherichia coli (−G). The results showed that some of the tested products are promising antibacterial drugs. |
| |
| Keywords: | |
|
|
