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Mild,four-component synthesis of 6-amino-4-aryl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles catalyzed by titanium dioxide nano-sized particles
Authors:Hamid Reza Shaterian  Kobra Azizi
Institution:1. Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, PO Box 98135-674, Zahedan, Iran
Abstract:A convenient and efficient solvent-free procedure is described for preparation of 6-amino-4-aryl-3-methyl-1,4-dihydropyrano2,3-c]pyrazole-5-carbonitriles by four-component reaction of hydrazine hydrate, ethyl acetoacetate, aryl aldehyde, and malononitrile in the presence of a catalytic amount of titanium dioxide nano-sized particles. Short reaction times, high yields under ambient conditions, simple reaction, clean work-up, and reusability of the nano heterogeneous catalyst are the advantages of this method.
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