Oxorhenium phosphinophenolato complexes with model peptide fragments: synthesis, characterization, and stability considerations |
| |
Authors: | Nock B Maina T Tisato F Raptopoulou C P Terzis A Chiotellis E |
| |
Institution: | Institute of Radioisotopes-Radiodiagnostic Products, National Centre for Scientific Research "Demokritos", 15310 Ag. Paraskevi, Athens, Greece. |
| |
Abstract: | The synthesis and characterization of a series of mixed-ligand oxorhenium(V) complexes containing the o-diphenylphosphinophenolato ligand (HL) and model peptide fragments acting as the tridentate coligand are reported. Thus, by reacting equimolar amounts of tiopronin, Gly-Gly, Gly-L-Phe, or glutathione (GSH) peptides on the (n-C4H9)4N]ReOCl3(L)] precursor in refluxing MeCN/MeOH or aqueous MeCN/MeOH mixtures, the following complexes were obtained: ReO(SC(CH3)CONCH2COO]L])(n-C4H9)4N], 1, ReO(H2NCH2CONCH2COO]L]), 2, ReO)H2NCH2CONCH(CH2C6H5)COO]L]), 3, and ReO(SCH2CH(NHCOCH2CH2CHNH2COOH)CONCH2COO]L])Na, 4. The compounds are closed-shell 18-electron oxorhenium species adopting a distorted octahedral geometry, as demonstrated by classical spectroscopical methods including multinuclear NMR. X-ray diffraction analyses for 1 and 2 are also reported. By comparative stability studies of complexes 1-3 against excess GSH it was shown that complex 3 containing the bulky C6H5CH2 substituent adjacent to the coordinated carboxylate group of Phe is the most stable complex. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|