| 拉呋替丁的波谱学数据和结构确证 |
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| 引用本文： | 赵如胜,杨日芳,恽榴红,刘河.拉呋替丁的波谱学数据和结构确证[J].波谱学杂志,2006,23(3):313-319. |
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| 作者姓名： | 赵如胜 杨日芳 恽榴红 刘河 |
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| 作者单位： | 军事医学科学院 毒物药物研究所，北京 100850 |
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| 摘 要： | 对拉呋替丁的氢谱（1H NMR）、碳谱（13C NMR，DEPT）、异核多键相关谱（HMBC）予以解析并进行了报道，对其所有的1H NMR和13C NMR谱信号进行了归属；讨论了红外特征吸收，热差和热重分析；质谱的裂解途径和离子特征也与拉呋替丁的分子结构相符.
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| 关 键 词： | 核磁共振 质谱 归属 拉呋替丁 |
| 文章编号： | 1000-4556（2006）03-0313-07 |
| 收稿时间： | 2005-11-13 |
| 修稿时间： | 2005-12-23 |
Spectroscopic Data Derived Structure of Lafutidine |
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| ZHAO Ru-sheng,YANG Ri-fang,YUN Liu-hong,LIU He.Spectroscopic Data Derived Structure of Lafutidine[J].Chinese Journal of Magnetic Resonance,2006,23(3):313-319. |
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| Authors: | ZHAO Ru-sheng YANG Ri-fang YUN Liu-hong LIU He |
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| Institution: | Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850,China |
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| Abstract: | Mass spectrum and one-dimensional (1H and 13 C ) and two-dimensional (heteronuclear multiple-bond coherence, HMBC) NMR spectra of lafutidine were reported and interpreted. The 1H and 13 C chemical shifts were assigned. The spectroscopic characteristics of the compound were discussed in detail and found to be consistent with its structure known previously. |
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| Keywords: | NMR mass spectrometry chemical shift assignment lafutidine |
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