First total synthesis of (+)-Vedelianin, a potent antiproliferative agent |
| |
Authors: | Topczewski Joseph J Wiemer David F |
| |
Institution: | Department of Chemistry, The University of Iowa, IA 52242-1294, United States |
| |
Abstract: | The total synthesis of (+)-vedelianin has been accomplished in 18 steps from vanillin. Preparation of a key intermediate in nonracemic form through a Shi epoxidation has allowed determination of the absolute stereochemistry of the natural product as the (2S,3R,4aR,9aR)-isomer. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|